For centuries, the pursuit of biological knowledge has been a process of zooming in from the organism to the organ, the tissue, the cell, and finally, with the advent of molecular biology, to the gene and the protein. This reductionist approach has been spectacularly successful, providing us with a parts list for life. We have sequenced genomes, catalogued proteins, and mapped metabolic pathways. Yet, a fundamental gap has persisted. Knowing the components of a watch is not the same as understanding the precise mechanics of its gears and springs in motion; likewise, knowing the sequence of a protein does not fully reveal how it functions as a dynamic, atomic-scale machine within the crowded, bustling environment of the cell.